OUR COMMITMENT

CONFIDENCE: INSIDE AND OUT

Welcome to Medspa 501, your home for restorative wellness & aesthetics.

a gorgeous african-american woman smiling

OUR APPROACH

CHAPEL HILL'S TRUSTED MEDSPA

We specialize in providing personalized anti-aging solutions tailored to you and your beauty goals. Here we blend the art of wellness, cutting-edge medical treatments, and the latest advances in prevention.

REFRESH AND REJUVENATE YOURSELF

LIMITED-TIME OFFERS

Medspa 501 is offering fantastic specials to help you refresh and rejuvenate! Enjoy exclusive discounts on our top treatments. Don't miss out—book your appointment today and take advantage of these limited-time offers!

OUR APPROACH

CHAPEL HILL'STRUSTED MEDSPA

We specialize in providing personalized anti-aging solutions tailored to you and your beauty goals. Here we blend the art of wellness, cutting-edge medical treatments, and the latest advances in prevention. Aging might not be optional, but aging well is.

REFRESH AND REJUVENATE YOURSELF

LIMITED-TIME OFFERS

MedSpa 501 is offering fantastic specials to help you refresh and rejuvenate! Enjoy exclusive discounts on our top treatments. Don't miss out—book your appointment today and take advantage of these limited-time offers!

OUR SERVICES

We offer a range of personalized medical aesthetics, anti-aging, and wellness services tailored to your unique needs. From rejuvenating facials to transformative injectables, we’re dedicated to enhancing your natural beauty through cutting-edge innovation.

Medspa 501 Testimonials

Find out why our clients keep coming back!

HIGHLY RECOMMEND!! My very first visit to Medspa 501!! My aesthetic injector was Samantha! After decades of working in plastics/dermatology, I had my least painful injections ever, and that is without topical numbing (at my request)!! My husband treated me to this special day after being on a 1 1/2 year weight loss journey!! I have full confidence in Medspa 501. Samantha is highly educated in aesthetic procedures, and facial anatomy - a class act!!
She listened well, offered her recommendations (with no pressure), and carried out the procedures in an expert and gentle manner. Besides her excellent and sterile techniques, she is so easy to talk to and has a great sense of humor.

Deb

The ONLY bad thing about MedSpa 501 is that Holly and Alex are equally my favorites so now I have to go twice as often to keep things fair. They are so knowledgeable and are phenomenal nurses, and every service I've gotten here (laser, chem peels, tox, IV therapy...) has been fabulous. Most recently, Alex told me that a couple units on each side of my mouth would prevent a downturn - well, color me amazed, I look five years younger and much nicer. Bye, RBF!

Claudette

Fantastic place. I have tried other places for “Botox” (the generic term) and never been happy with the staff or results. I love MediSpa 501. The staff is knowledgeable & personable (love Alex). They will not push extra services on you. They want what is the best for you and your budget. I am 51 and feel my skin is in the best shape it has ever been. Is it cheap? No. But is it worth it. Absolutely. I am a repeat client and will Continue to be. 10 stars!

Tammy

Such an incredible experience from start to finish. I got a Hydro Facial and it was everything I didn’t know I needed. It was so relaxing and completely refreshing. Days later and my skin is still glowing!!. The staff made me feel instantly welcome and completely at ease. The space is gorgeous and the vibes are immaculate! This was my first visit and definitely not my last!!

Josie

I love this place and will definitely be returning! Upon entering, I was kindly greeted by the front desk. She got me checked in and situated in the room where I would be getting my treatment done. I got a lip flip done by Julia who is absolutely amazing. She made everything very comfortable for me, not to mention she has an amazing personality. To top it all off, the aesthetic of the spa is a whole vibe. 10/10 highly recommended!

Jayla

From the moment I arrived, the front desk team greeted me warmly and got me settled right away. Holly took the time to thoroughly explain the process and the different options available, which made me feel really comfortable and informed. The Hydrafacial itself was incredible — my skin feels so clean, refreshed, and glowing. Holly was very attentive, making sure I was relaxed and comfortable throughout the entire treatment.

Mary



I went to Medspa 501 for a consultation to address different skincare treatment options. I met with Alex and she was the sweetest and so knowledgeable as well! So easy going and gave me some great options to choose from. Looking forward to my upcoming micro-needling appointment next week!

Gina



Went for a hydrafacial this morning with the amazing Alex and came out GLOWING! The whole feel of the office is calming and relaxing. Can't wait to go back for a peel!

Jessie


A great place with wonderful people who help you to become the best version of yourself! By the end of my treatment, the Medspa team felt like family, and each individual person made my experience smooth and effortless. I highly recommend Medspa 501 for any and all of your health and beauty needs! I am very grateful for this place.

Bettina


Staffs’ knowledge, application and attention to detail on IV nutrient therapy exceeded my expectations. They are not only highly skilled but also super friendly. In addition, this is a to-go place for empowering men’s health – the best in town. The customer service was outstanding, and the product was exactly what I was looking for.

Quan


This was one of the most positive experiences I have ever had and I will certainly return frequently! The entire staff was fantastic, helpful, friendly, personable, and kind, and that made the entire process all the more relaxing and rejuvenating. I cannot thank you enough for the atmosphere you’ve created and the work that you do!

Byron

Professionals You Can Trust

We’re proud to be recognized by both our peers and our patients — with credentials you can trust and awards that reflect the care we give.

Award "Most Innovative Solutions for Companies"

Best Spa, Chapel Hill Magazine (2025)

Award "Best Service Provider"

Best New Business, Chapel Hill Magazine (2025)

Award "Comfortable and Modern Office Design"

Certification, The Institute for Functional Medicine

Award "Comfortable and Modern Office Design"

Certification, 3x4 Genetics

MedSpa 501 and 501 Pharmacy

PARTNERING FOR YOU

The combination of Medspa 501 and 501 Pharmacy provides a unique benefit for our clients, including custom cosmeceuticals, IV formulations, and more. Let us guide you on a path to renewed vitality and confidence!

AESTHETIC SERVICES IN CHAPEL HILL, FEARRINGTON, BRIAR CHAPEL AND PITTSBORO NORTH CAROLINA

CONTACT MEDSPA 501

medspa 501 in Chapel Hill

FAX

(984) 336-0500

HOURS

Monday - Friday 9:00 AM - 6:00 PMSaturday and SundayClosed

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We will answer any of your questions.