Chapel Hill Med Spa for
Aesthetics & Longevity Medicine
Medical-led aesthetic and wellness care in Chapel Hill designed to help you look, feel, and function at your best—at every stage of life.
START WITH WHAT MATTERS TO YOUTwo Paths. One Goal: You.
Aesthetics
Enhance your natural beauty and feel confident in your skin.
• Injectables & Fillers
• Facial Treatments
• Microneedling
• Regenerative Aesthetics
• PRF & More
Longevity & Functional Medicine
Optimize how you feel today and support your health for life.
• 1Wellness Program
• Hormone Optimization
• Medical Weight Loss
• IV Nutrient Therapy & More
OUR SIGNATURE APPROACHThe 1Wellness Program
1Wellness is our advanced, membership-based wellness program that merges Functional Medicine and Precision Medicine into a fully individualized health plan. Whether your goal is healing, prevention, or peak performance, we integrate root-cause diagnostics and modern technologies to guide you.
Advanced Lab Testing
Personalized Care Plans
Targeted Treatments
Ongoing Optimization
ADVANCED TREATMENTS.
PERSONALIZED FOR YOU.Explore Our Most Popular Services
Aesthetic Treatments
Medspa 501 offers a full range of aesthetic treatments designed to enhance your natural features while maintaining balance and authenticity. Every treatment is guided by medical expertise and tailored to your goals, whether you’re seeking subtle refinement or more advanced rejuvenation.
As a leading medical spa in Chapel Hill, we offer:
Longevity & Functional Medicine
Our approach combines longevity medicine and functional medicine to help you improve how you feel today while building a long-term strategy for your health. Through the 1Wellness Program and targeted therapies, care is guided by advanced diagnostics, clinical insight, and ongoing optimization.
Our care is rooted in longevity medicine and functional medicine, delivered through the structured 1Wellness Program and supported by targeted therapies.
Testimonials
Find out why our clients keep coming back.
The Medspa 501 Difference
At Medspa 501, we believe exceptional results come from combining medical expertise with a thoughtful, individualized approach to care. Every treatment is guided by science, delivered by experienced providers, and designed around your goals—not trends or one-size-fits-all solutions.
Our Approach to Care:
→ Medical-led care with experienced, licensed providers
→ Personalized treatment plans grounded in clinical expertise
→ Integrated care that connects aesthetics and medical wellness
→ A welcoming, down-to-earth environment built on trust
Professionals You Can Trust
We’re proud to be recognized by both our peers and our patients — with credentials you can trust and awards that reflect the care we give.
Best New Business, Chapel Hill Magazine (2025)
Best Spa, Chapel Hill Magazine (2025)
Certification,
The Institute for Functional Medicine
Certification,
3x4 Genetics
Not sure where to start?
We’ll help guide you.
About Medspa 501
Medspa 501 was built on the belief that aesthetic care and medical wellness work best when they are thoughtfully integrated. Our team combines clinical expertise with a personalized approach, helping patients feel confident in both how they look and how they feel.
Medspa 501 & 501 Pharmacy: A partnership for you
Our on-site partnership with 501 Pharmacy provides seamless coordination of care, from prescriptions to personalized treatment support. This collaboration helps ensure accuracy, continuity, and a higher standard of medical oversight throughout your experience.
Visit Medspa 501
We’re here to make your visit simple and supportive from the moment you connect with our team. Whether you’re exploring aesthetic treatments or medical wellness services, you’ll receive clear guidance tailored to your goals.
Conveniently located in Chapel Hill, we proudly serve patients from Carrboro, Pittsboro, and surrounding communities.
PHONE
69 Knox Way, STE 108
Chapel Hill, NC 27516
ADDRESS
FAX
Monday - Friday: 9:00 AM - 5:00 PM
Saturday - Sunday: Closed
HOURS